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Prof. Dr. Ruth Freitag

Prof. Dr. Ruth Freitag Prof. Dr. Ruth Freitag
Prof. Dr. Ruth Freitag

Faculty of Engineering Science
Chair for Process Biotechnology


Job History

seit 2003

Professorin, Lehrstuhl für Bioprozesstechnik, Ingenieurwissenschaftliche Fakultät, Universität Bayreuth

2002Director of the Institute of Chemical and Biological Process science (ISP) in the Faculty of Basic Science, Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland
05/1996 – 12/2005Assistant / Associate Professor for Chemical Biotechnology, Department of Chemistry, Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland
06/1995 – 05/1996

Privatdozentin, Technische Chemie/Biotechnologie,
Universität Hannover


Education

07/1991 – 05/1995

Habilitation, Technische Chemie/Biotechnologie,
Universität Hannover

03/1990 – 06/1991

PostDoc, Yale University, Department of Chemical Engineering, Prof. Csaba Horvath, New Haven, CT, USA

10/1987 – 02/1990

Promotion, Technische Chemie/Biotechnologie, Universität Hannover

1987Diplom: Chemie, Universität Hannover, Diplomarbeit: Prof. Karl Schügerl

Awards and other responsibilities

seit 2012Mitglied des Forschungsbeirates zum Fraunhofer Systemforschungsprojekt „Zellfreie Bioproduktion“
seit 2008Mitglied (Expertin) der ASIIN, Akkreditierungsorganisation für Bachelor- und Master-Studiengänge in den Bereichen Informatik, Mathematik, Ingenieur- und Naturwissenschaften
seit 2004Mitglied im Bayreuther Zentrum für Molekulare Biowissenschaften (BZMB), Zuordnung zur kollegialen Leitung
seit 2003Mitglied der vom Bundesrat gewählten Eidgenössischen Kommission für Technologie und Innovation (KTI) im Eidgenössischen Volkswirtschaftsdepartement, Bern, Schweiz
Prof. Dr. Ruth Freitag

Faculty of Engineering Science
Chair for Process Biotechnology


Selected publications

2024

Steiner, Thomas; Leitner, Lisa-Cathrin; Zhang, Yuanhu; Möller, Julia N.; Löder, Martin G. J.; Greiner, Andreas; Laforsch, Christian; Freitag, Ruth
Detection and specific chemical identification of submillimeter plastic fragments in complex ma ...
in Scientific Reports volume 14 (2024)
doi:10.1038/s41598-024-51185-6 ...

Jasinski, Julia; Völkl, Matthias; Wilde, Magdalena V.; Jérôme, Valérie; Fröhlich, Thomas; Freitag, Ruth; Scheibel, Thomas
Influence of the polymer type of a microplastic challenge on the reaction of murine cells
in Journal of Hazardous Materials volume 465 (2024)
doi:10.1016/j.jhazmat.2023.133280 ...

Mondellini, Simona; Schwarzer, Michael; Völkl, Matthias; Jasinski, Julia; Jérôme, Valérie; Scheibel, Thomas; Laforsch, Christian; Freitag, Ruth
Size dependent uptake and trophic transfer of polystyrene microplastics in unicellular freshwat ...
in Science of the Total Environment (2024)
doi:10.1016/j.scitotenv.2024.172470 ...

2023

Helm, Moritz; Huang, Songyan Ben; Gollner, Katrin; Gollner, Ulrich; Jérôme, Valérie; Freitag, Ruth
Cultivation of Encapsulated Primary Human B Lymphocytes : A First Step toward a Bioartificial G ...
in Macromolecular Bioscience volume 23 (2023) issue 1
doi:10.1002/mabi.202200256 ...

Leitner, Lisa-Cathrin; Schneider, Rika; Steiner, Thomas; Stenzel, Martina H.; Freitag, Ruth; Greiner, Andreas
Efficient Synthesis and Wetting Characteristics of Amphiphilic Galactose-PLA Block Copolymers : ...
in Macromolecular Chemistry and Physics volume 224 (2023) issue 1
doi:10.1002/macp.202100431 ...

Steiner, Thomas; Möller, Julia N.; Löder, Martin G. J.; Hilbrig, Frank; Laforsch, Christian; Freitag, Ruth
Microplastic Contamination of Composts and Liquid Fertilizers from Municipal Biowaste Treatment ...
in Waste and Biomass Valorization volume 14 (2023) . - page 873-887
doi:10.1007/s12649-022-01870-2 ...

Jasinski, Julia; Völkl, Matthias; Hahn, Jonas; Jérôme, Valérie; Freitag, Ruth; Scheibel, Thomas
Polystyrene microparticle distribution after ingestion by murine macrophages
in Journal of Hazardous Materials volume 457 (2023)
doi:10.1016/j.jhazmat.2023.131796 ...

Zhang, Yuanhu; Paul, Tasmai; Brehm, Julian; Völkl, Matthias; Jérôme, Valérie; Freitag, Ruth; Laforsch, Christian; Greiner, Andreas
Role of Residual Monomers in the Manifestation of (Cyto)toxicity by Polystyrene Microplastic Mo ...
in Environmental Science & Technology volume 57 (2023) issue 27. - page 9925-9933
doi:10.1021/acs.est.3c01134 ...

Xu, Chengzhang; Cheong, Jun Young; Mo, Xiumei; Jérôme, Valérie; Freitag, Ruth; Agarwal, Seema; Gharibi, Reza; Greiner, Andreas
Thoroughly Hydrophilized Electrospun Poly(L-Lactide)/ Poly(ε-Caprolactone) Sponges for Tissue E ...
in Macromolecular Bioscience volume 23 (2023) issue 11
doi:10.1002/mabi.202300143 ...

2022

Müller, Ann-Kathrin; Brehm, Julian; Völkl, Matthias; Jérôme, Valérie; Laforsch, Christian; Freitag, Ruth; Greiner, Andreas
Disentangling biological effects of primary nanoplastics from dispersion paints' additional com ...
in Ecotoxicology and Environmental Safety volume 242 (2022)
doi:10.1016/j.ecoenv.2022.113877 ...

Simeon, Meshack Imologie; Herkendell, Katharina; Pant, Deepak; Freitag, Ruth
Electrochemical evaluation of different polymer binders for the production of carbon-modified s ...
in Chemical Engineering Journal Advances volume 10 (2022)
doi:10.1016/j.ceja.2022.100246 ...

Liao, Xiaojian; Jérôme, Valérie; Agarwal, Seema; Freitag, Ruth; Greiner, Andreas
High Strength and High Toughness Electrospun Multifibrillar Yarns with Highly Aligned Hierarchy ...
in Macromolecular Bioscience volume 22 (2022) issue 12
doi:10.1002/mabi.202200291 ...

Riedl, Simon; Völkl, Matthias; Holzinger, Anja; Jasinski, Julia; Jérôme, Valérie; Scheibel, Thomas; Feldhaar, Heike; Freitag, Ruth
In vitro cultivation of primary intestinal cells from Eisenia fetida as basis for ecotoxicologi ...
in Ecotoxicology volume 31 (2022) . - page 221-233
doi:10.1007/s10646-021-02495-2 ...

Simeon, Meshack Imologie; Freitag, Ruth
Influence of electrode spacing and fed-batch operation on the maximum performance trend of a so ...
in International Journal of Hydrogen Energy volume 47 (2022) issue 24. - page 12304-12316
doi:10.1016/j.ijhydene.2021.11.110 ...

Mlinar, Stanislava; Weig, Alfons; Freitag, Ruth
Influence of NH₃ and NH₄⁺ on anaerobic digestion and microbial population structure at increasi ...
in Bioresource Technology volume 361 (2022)
doi:10.1016/j.biortech.2022.127638 ...

Schöpfer, Lion; Möller, Julia N.; Steiner, Thomas; Schnepf, Uwe; Marhan, Sven; Resch, Julia; Bayha, Ansilla; Löder, Martin G. J.; Freitag, Ruth; Brümmer, Franz; Laforsch, Christian; Streck, Thilo; Forberger, Jens; Kranert, Martin; Kandeler, Ellen; Pagel, Holger
Microplastics persist in an arable soil but do not affect soil microbial biomass, enzyme activi ...
in Journal of Plant Nutrition and Soil Science volume 185 (2022) issue 6. - page 836-849
doi:10.1002/jpln.202200062 ...

Steiner, Thomas; Zhang, Yuanhu; Möller, Julia N.; Agarwal, Seema; Löder, Martin G. J.; Greiner, Andreas; Laforsch, Christian; Freitag, Ruth
Municipal biowaste treatment plants contribute to the contamination of the environment with res ...
in Scientific Reports volume 12 (2022)
doi:10.1038/s41598-022-12912-z ...

Simeon, Meshack Imologie; Weig, Alfons; Freitag, Ruth
Optimization of soil microbial fuel cell for sustainable bio-electricity production: combined e ...
in Biotechnology for Biofuels and Bioproducts volume 15 (2022)
doi:10.1186/s13068-022-02224-9 ...

Riedl, Simon; Jérôme, Valérie; Freitag, Ruth
Repeated Transient Transfection : An Alternative for the Recombinant Production of Difficult-to ...
in Processes volume 10 (2022) issue 6
doi:10.3390/pr10061064 ...

Ramsperger, Anja; Jasinski, Julia; Völkl, Matthias; Witzmann, Thomas; Meinhart, Marcel; Jérôme, Valérie; Kretschmer, Winfried; Freitag, Ruth; Senker, Jürgen; Fery, Andreas; Kress, Holger; Scheibel, Thomas; Laforsch, Christian
Supposedly identical microplastic particles substantially differ in their material properties i ...
in Journal of Hazardous Materials volume 425 (2022)
doi:10.1016/j.jhazmat.2021.127961 ...

Jasinski, Julia; Wilde, Magdalena V.; Völkl, Matthias; Jérôme, Valérie; Fröhlich, Thomas; Freitag, Ruth; Scheibel, Thomas
Tailor-Made Protein Corona Formation on Polystyrene Microparticles and its Effect on Epithelial ...
in ACS Applied Materials & Interfaces volume 14 (2022) issue 41. - page 47277-47287
doi:10.1021/acsami.2c13987 ...

Schöpfer, Lion; Möller, Julia N.; Steiner, Thomas; Schnepf, Uwe; Marhan, Sven; Resch, Julia; Bayha, Ansilla; Löder, Martin G. J.; Freitag, Ruth; Brümmer, Franz; Laforsch, Christian; Streck, Thilo; Forberger, Jens; Kranert, Martin; Kandeler, Ellen; Pagel, Holger
Microplastics persist in an arable soil but do not affect soil microbial biomass, enzyme activi ...
in Journal of Plant Nutrition and Soil Science volume 185 (2022) issue 6. - page 836-849
doi:10.1002/jpln.202200062 ...

Völkl, Matthias; Jérôme, Valérie; Weig, Alfons; Jasinski, Julia; Meides, Nora; Strohriegl, Peter; Scheibel, Thomas; Freitag, Ruth
Pristine and artificially-aged polystyrene microplastic particles differ in regard to cellular ...
in Journal of Hazardous Materials volume 435 (2022)
doi:10.1016/j.jhazmat.2022.128955 ...

Riese, Cornelius N.; Wittchen, Manuel; Jérôme, Valérie; Freitag, Ruth; Busche, Tobias; Kalinowski, Jörn; Schüler, Dirk
The transcriptomic landscape of Magnetospirillum gryphiswaldense during magnetosome biominerali ...
in BMC Genomics volume 23 (2022)
doi:10.1186/s12864-022-08913-x ...

2021

Diaz Ariza, Ivonne L.; Jérôme, Valérie; Pérez Pérez, León D.; Freitag, Ruth
Amphiphilic Graft Copolymers Capable of Mixed-Mode Interaction as Alternative Nonviral Transfec ...
in ACS Applied Bio Materials volume 4 (2021) issue 2. - page 1268-1282
doi:10.1021/acsabm.0c01123 ...

Simeon, Meshack Imologie; Imoize, Agbotiname Lucky; Freitag, Ruth
Comparative evaluation of the performance of a capacitive and a non-capacitive microbial fuel c ...
18th International Multi-Conference on Systems, Signals & Devices (SSD 2021)
Piscataway, NJ : IEEE, 2021. - page 1076-1082
doi:10.1109/SSD52085.2021.9429481 ...

Diaz, Ivonne L.; Jérôme, Valérie; Freitag, Ruth; Perez, León D.
Development of poly(ethyleneimine) grafted amphiphilic copolymers : Evaluation of their cytotox ...
in Journal of Bioactive and Compatible Polymers volume 36 (2021) issue 6. - page 447-463
doi:10.1177/08839115211053925 ...

Keim, Daniel; Gollner, Katrin; Gollner, Ulrich; Jérôme, Valérie; Freitag, Ruth
Generation of Recombinant Primary Human B Lymphocytes Using Non-Viral Vectors
in International Journal of Molecular Sciences volume 22 (2021) issue 15
doi:10.3390/ijms22158239 ...

Helm, Moritz; Riedl, Simon; Gollner, Katrin; Gollner, Ulrich; Jérôme, Valérie; Freitag, Ruth
Isolation of primary human B lymphocytes from tonsils compared to blood as alternative source f ...
in Journal of Chromatography B volume 1179 (2021)
doi:10.1016/j.jchromb.2021.122853 ...

Rudolph, Julia; Völkl, Matthias; Jérôme, Valérie; Scheibel, Thomas; Freitag, Ruth
Noxic effects of polystyrene microparticles on murine macrophages and epithelial cells
in Scientific Reports volume 11 (2021)
doi:10.1038/s41598-021-95073-9 ...

Rosenfeldt, Sabine; Mickoleit, Frank; Jörke, Cornelia; Clement, Joachim H.; Markert, Simon; Jérôme, Valérie; Schwarzinger, Stephan; Freitag, Ruth; Schüler, Dirk; Uebe, René; Schenk, Anna
Towards standardized purification of bacterial magnetic nanoparticles for future in vivo applic ...
in Acta Biomaterialia volume 120 (2021) . - page 293-303
doi:10.1016/j.actbio.2020.07.042 ...

Weithmann, Nicolas; Mlinar, Stanislava; Sonnleitner, Eva; Weig, Alfons; Freitag, Ruth
Flexible feeding in anaerobic digestion : Impact on process stability, performance and microbia ...
in Anaerobe volume 68 (2021)
doi:10.1016/j.anaerobe.2020.102297 ...

2020

Riese, Cornelius N.; Uebe, René; Rosenfeldt, Sabine; Schenk, Anna; Jérôme, Valérie; Freitag, Ruth; Schüler, Dirk
An automated oxystat fermentation regime for microoxic cultivation of Magnetospirillum gryphisw ...
in Microbial Cell Factories volume 19 (2020)
doi:10.1186/s12934-020-01469-z ...

Mickoleit, Frank; Jérôme, Valérie; Freitag, Ruth; Schüler, Dirk
Bacterial Magnetosomes as Novel Platform for the Presentation of Immunostimulatory, Membrane-Bo ...
in Advanced Biosystems volume 4 (2020) issue 3
doi:10.1002/adbi.201900231 ...

Mlinar, Stanislava; Weig, Alfons; Freitag, Ruth
Influence of mixing and sludge volume on stability, reproducibility, and productivity of labora ...
in Bioresource Technology Reports volume 11 (2020)
doi:10.1016/j.biteb.2020.100444 ...

Mader, Michael; Helm, Moritz; Lu, Mingxia; Stenzel, Martina H.; Jérôme, Valérie; Agarwal, Seema; Freitag, Ruth; Greiner, Andreas
Perfusion Cultivation of Artificial Liver ECM in Fibrous Polymer Sponges Biomimicking Scaffolds ...
in Biomacromolecules volume 21 (2020) issue 10. - page 4094-4104
doi:10.1021/acs.biomac.0c00900 ...

Simeon, Meshack Imologie; Asoiro, Felix U.; Aliyu, Mohamad; Raji, Olayinka A.; Freitag, Ruth
Polarization and power density trends of a soil-based microbial fuel cell treated with human ur ...
in International Journal of Energy Research volume 44 (2020) issue 7. - page 5968-5976
doi:10.15495/EPub_UBT_00005040 ...

Diaz, Ivonne L.; Sierra, Cesar A.; Jérôme, Valérie; Freitag, Ruth; Perez, León D.
Target grafting of poly(2-(dimethylamino)ethyl methacrylate) to biodegradable block copolymers
in Journal of Polymer Science volume 58 (2020) issue 16. - page 2168-2180
doi:10.1002/pol.20200204 ...

Jérôme, Valérie; Synatschke, Christopher V.; Freitag, Ruth
Transient Destabilization of Biological Membranes Contributes to the Superior Performance of St ...
in ACS Omega volume 5 (2020) issue 41. - page 26640-26654
doi:10.1021/acsomega.0c03367 ...

2019

Weithmann, Nicolas; Mlinar, Stanislava; Hilbrig, Frank; Bachmaf, Samer; Arndt, Julia; Planer-Friedrich, Britta; Weig, Alfons; Freitag, Ruth
Arsenic metabolism in technical biogas plants : possible consequences for resident microbiota a ...
in AMB Express volume 9 (2019)
doi:10.1186/s13568-019-0902-6 ...

Reich, Steffen; Kaiser, Patrick; Mafi, Mahsa; Schmalz, Holger; Rhinow, Daniel; Freitag, Ruth; Greiner, Andreas
High‐Temperature Spray‐Dried Polymer/Bacteria Microparticles for Electrospinning of Composite N ...
in Macromolecular Bioscience volume 19 (2019) issue 5
doi:10.1002/mabi.201800356 ...

Jérôme, Valérie; Freitag, Ruth; Schüler, Dirk; Mickoleit, Frank
SEAP activity measurement in reporter cell-based assays using BCIP / NBT as substrate
in Analytical Biochemistry volume 585 (2019)
doi:10.1016/j.ab.2019.113402 ...

2018

Chen, Baizhu; Synatschke, Christopher V.; Jérôme, Valérie; Müller, Axel H. E.; Freitag, Ruth; Wu, Chi
Co-transfection of star-shaped PDMAEMAs enhance transfection efficiency of protamine/pDNA compl ...
in European Polymer Journal volume 103 (2018) . - page 362-369
doi:10.1016/j.eurpolymj.2018.04.022 ...

Riedl, Simon; Kaiser, Patrick; Raup, Alexander; Synatschke, Christopher V.; Jérôme, Valérie; Freitag, Ruth
Non-Viral Transfection of Human T Lymphocytes
in Processes volume 6 (2018) issue 10
doi:10.3390/pr6100188 ...

Stoppok, Manfred; Jess, Andreas; Freitag, Ruth; Alber, Erdmute
Of culture, consumption and cost : A comparative Analysis of household energy consumption in Ke ...
in Energy Research & Social Science volume 40 (2018) . - page 127-139
doi:10.1016/j.erss.2017.12.004 ...

Weithmann, Nicolas; Möller, Julia N.; Löder, Martin G. J.; Piehl, Sarah; Laforsch, Christian; Freitag, Ruth
Organic fertilizer as a vehicle for the entry of microplastic into the environment
in Science Advances volume 4 (2018) issue 4
doi:10.1126/sciadv.aap8060 ...

Pretscher, Martin; Pineda-Contreras, Beatriz A.; Kaiser, Patrick; Reich, Steffen; Schöbel, Judith; Kuttner, Christian; Freitag, Ruth; Fery, Andreas; Schmalz, Holger; Agarwal, Seema
pH-Responsive Biohybrid Carrier Material for Phenol Decontamination in Wastewater
in Biomacromolecules volume 19 (2018) issue 8. - page 3224-3232
doi:10.1021/acs.biomac.8b00361 ...

Kaiser, Patrick; Reich, Steffen; Greiner, Andreas; Freitag, Ruth
Preparation of Biocomposite Microfibers Ready for Processing into Biologically Active Textile F ...
in Macromolecular Bioscience volume 18 (2018) issue 7
doi:10.1002/mabi.201800046 ...

Kaiser, Patrick; Werner, Melanie; Jérôme, Valérie; Freitag, Ruth
Scale‐up of the ex vivo expansion of encapsulated primary human T lymphocytes
in Biotechnology and Bioengineering volume 115 (2018) issue 10. - page 2632-2642
doi:10.1002/bit.26786 ...

Mader, Michael; Jérôme, Valérie; Freitag, Ruth; Agarwal, Seema; Greiner, Andreas
Ultraporous, compressible, wettable polylactide/polycaprolactone sponges for tissue engineering
in Biomacromolecules volume 19 (2018) issue 5. - page 1663-1673
doi:10.1021/acs.biomac.8b00434 ...

2017

Raup, Alexander; Wang, Hui; Synatschke, Christopher V.; Jérôme, Valérie; Agarwal, Seema; Pergushov, Dmitry V.; Müller, Axel H. E.; Freitag, Ruth
Compaction and transmembrane delivery of pDNA : differences between l-PEI and two types of amph ...
in Biomacromolecules volume 18 (2017) issue 3. - page 808-818
doi:10.1021/acs.biomac.6b01678 ...

Jérôme, Valérie; Thoring, Lena; Salzig, Denise; Kubick, Stefan; Freitag, Ruth
Comparison of cell-based versus cell-free mammalian systems for the production of a recombinant ...
in Engineering in Life Sciences volume 17 (2017) issue 10. - page 1097-1107
doi:10.1002/elsc.201700005 ...

Jérôme, Valérie; Werner, Melanie; Kaiser, Patrick; Freitag, Ruth
Creating a Biomimetic Microenvironment for the Ex Vivo Expansion of Primary Human T Lymphocytes
in Macromolecular Bioscience volume 17 (2017) issue 9
doi:10.1002/mabi.201700091 ...

Kaiser, Patrick; Reich, Steffen; Leykam, Daniel; Willert-Porada, Monika; Greiner, Andreas; Freitag, Ruth
Electrogenic Single-Species Biocomposites as Anodes for Microbial Fuel Cells
in Macromolecular Bioscience volume 17 (2017) issue 7
doi:10.1002/mabi.201600442 ...

Stahlschmidt, Ullrich; Jérôme, Valérie; Majewski, Alexander P.; Müller, Axel H. E.; Freitag, Ruth
Systematic Study of a Library of PDMAEMA-Based, Superparamagnetic Nano-Stars for the Transfecti ...
in Polymers volume 9 (2017) issue 5
doi:10.3390/polym9050156 ...

2016

Raup, Alexander; Stahlschmidt, Ullrich; Jérôme, Valérie; Synatschke, Christopher V.; Müller, Axel H. E.; Freitag, Ruth
Influence of Polyplex Formation on the Performance of Star-Shaped Polycationic Transfection Agen ...
in Polymers volume 8 (2016) issue 6
doi:10.3390/polym8060224 ...

Weithmann, Nicolas; Weig, Alfons; Freitag, Ruth
Process parameters and changes in the microbial community patterns during the first 240 days of ...
in AMB Express volume 6 (2016)
doi:10.1186/s13568-016-0219-7 ...

Zambrano, Kenny; Jérôme, Valérie; Freitag, Ruth; Buchholz, Rainer; Jäck, Hans-Martin; Hübner, Holger; Schuh, Wolfgang
Prolonged Ex vivo expansion and differentiation of naïve murine CD43− B splenocytes
in Biotechnology Progress volume 32 (2016) issue 4. - page 978-989
doi:10.1002/btpr.2265 ...

Raup, Alexander; Jérôme, Valérie; Freitag, Ruth; Synatschke, Christopher V.; Müller, Axel H. E.
Promoter, transgene, and cell line effects in the transfection of mammalian cells using PDMAEMA ...
in Biotechnology Reports volume 11 (2016) . - page 53-61
doi:10.1016/j.btre.2016.05.003 ...

2015

Shi, Yinfeng; Zhou, Peiran; Jérôme, Valérie; Freitag, Ruth; Agarwal, Seema
Enzymatically Degradable Polyester-Based Adhesives
in ACS Biomaterials Science & Engineering volume 1 (2015) issue 10. - page 971-977
doi:10.1021/acsbiomaterials.5b00217 ...

Werner, Melanie; Schmoldt, Daria; Hilbrig, Frank; Jérôme, Valérie; Raup, Alexander; Zambrano, Kenny; Hübner, Holger; Buchholz, Rainer; Freitag, Ruth
High Cell Density Cultivation of Human Leukemia T Cells (Jurkat Cells) in Semipermeable Polyele ...
in Engineering in Life Sciences volume 15 (2015) issue 4. - page 357-367
doi:10.1002/elsc.201400186 ...

Käfer, Florian; Liu, Fangyao; Stahlschmidt, Ullrich; Jérôme, Valérie; Freitag, Ruth; Karg, Matthias; Agarwal, Seema
LCST and UCST in one : Double thermoresponsive behavior of block copolymers of poly(ethylene gl ...
in Langmuir volume 31 (2015) issue 32. - page 8940-8946
doi:10.1021/acs.langmuir.5b02006 ...

Knierim, Christian; Enzeroth, Michaela; Kaiser, Patrick; Dams, Christian; Nette, David; Seubert, Andreas; Klingl, Andreas; Greenblatt, Charles; Jérôme, Valérie; Agarwal, Seema; Freitag, Ruth; Greiner, Andreas
Living Composites of Bacteria and Polymers as Biomimetic Films for Metal Sequestration and Bior ...
in Macromolecular Bioscience volume 15 (2015) issue 8. - page 1052-1059
doi:10.1002/mabi.201400538 ...

Pineda Contreras, Paul; Kuttner, Christian; Fery, Andreas; Stahlschmidt, Ullrich; Jérôme, Valérie; Freitag, Ruth; Agarwal, Seema
Renaissance for Low Shrinking Resins : all-in-one Solution by Bi-Functional Vinylcyclopropane-A ...
in Chemical Communications volume 51 (2015) issue 59. - page 11899-11902
doi:10.1039/C5CC03901K ...

Duan, Gaigai; Jiang, Shaohua; Jérôme, Valérie; Wendorff, Joachim H.; Fathi, Amir; Uhm, Jacqueline S.; Altstädt, Volker; Herling, Markus M.; Breu, Josef; Freitag, Ruth; Agarwal, Seema; Greiner, Andreas
Ultralight, Soft Polymer Sponges by Self-Assembly of Short Electrospun Fibers in Colloidal Disp ...
in Advanced Functional Materials volume 25 (2015) issue 19. - page 2850-2856
doi:10.1002/adfm.201500001 ...

2014

Kaiser, Patrick; Werner, Melanie; Jérôme, Valérie; Hübner, Holger; Buchholz, Rainer; Freitag, Ruth
Cell Retention by Encapsulation for the Cultivation of Jurkat Cells in Fixed and Fluidized Bed ...
in Biotechnology and Bioengineering volume 111 (2014) issue 12. - page 2571-2579
doi:10.1002/bit.25304 ...

Freitag, Ruth
Chromatographic techniques in the downstream processing of proteins in biotechnology
Animal cell biotechnology : methods and protocols
New York, NY : Humana Press, 2014. - page 419-458 . - (Methods in Molecular Biology; 1104)
doi:10.1007/978-1-62703-733-4_25 ...

Wang, Hui; Synatschke, Christopher V.; Raup, Alexander; Jérôme, Valérie; Freitag, Ruth; Agarwal, Seema
Oligomeric dual functional antibacterial polycaprolactone
in Polymer Chemistry volume 5 (2014) issue 7. - page 2453-2460
doi:10.1039/C3PY01467C ...

2013

Majewski, Alexander P.; Stahlschmidt, Ullrich; Jérôme, Valérie; Freitag, Ruth; Müller, Axel H. E.; Schmalz, Holger
PDMAEMA-Grafted Core-Shell-Corona Particles for Nonviral Gene Delivery and Magnetic Cell Separa ...
in Biomacromolecules volume 14 (2013) issue 9. - page 3081-3090
doi:10.1021/bm400703d ...

Werner, Melanie; Biss, Karsten; Jérôme, Valérie; Hilbrig, Frank; Freitag, Ruth; Zambrano, Kenny; Hübner, Holger; Buchholz, Rainer; Mahou, Redouan; Wandrey, Christine
Use of the mitochondria toxicity assay for quantifying the viable cell density of microencapsul ...
in Biotechnology Progress volume 29 (2013) issue 4. - page 986-993
doi:10.1002/btpr.1734 ...

2012

Majewski, Alexander P.; Schallon, Anja; Jérôme, Valérie; Freitag, Ruth; Müller, Axel H. E.; Schmalz, Holger
Dual-responsive magnetic core-shell nanoparticles for non-viral gene delivery and cell separati ...
in Abstracts of Papers of the American Chemical Society volume 243 (2012) . - page 40-POLY
Symposium on Ionic Liquids - Science and Applications / 243rd National Spring Meeting of the American-Chemical-Society, San Diego, CA, MAR 25-29, 2012, San Diego, CA,

Majewski, Alexander P.; Schallon, Anja; Jérôme, Valérie; Freitag, Ruth; Müller, Axel H. E.; Schmalz, Holger
Dual-Responsive Magnetic Core-Shell Nanoparticles for Nonviral Gene Delivery and Cell Separatio ...
in Biomacromolecules volume 13 (2012) issue 3. - page 857-866
doi:10.1021/bm2017756 ...

Freimark, Denise; Jérôme, Valérie; Freitag, Ruth
Effect of process parameters and product-host-interaction on hVEGFA-production by recombinant C ...
in Biotechnology Progress volume 28 (2012) issue 3. - page 762-772
doi:10.1002/btpr.1524 ...

Hilbrig, Frank; Freitag, Ruth
Isolation and purification of recombinant proteins, antibodies and plasmid DNA with hydroxyapat ...
in Biotechnology Journal volume 7 (2012) issue 1. - page 90-102
doi:10.1002/biot.201100015 ...

Schallon, Anja; Synatschke, Christopher V.; Jérôme, Valérie; Müller, Axel H. E.; Freitag, Ruth
Nanoparticulate Nonviral Agent for the Effective Delivery of pDNA and siRNA to Differentiated C ...
in Biomacromolecules volume 13 (2012) issue 11. - page 3463-3474
doi:10.1021/bm3012055 ...

Freitag, Ruth; Jérôme, Valérie; Müller, Axel H. E.; Schmalz, Holger
Polymermodifizierte magnetische Nanopartikel
in GIT : Labor-Fachzeitschrift volume 56 (2012) issue 8. - page 602
https://www.git-labor.de/forschung/life-sciences-b ...

2011

Arnold, Marc; Bittermann, Holger; Kalbfuss-Zimmermann, Bernd; Neumann, Thomas; Schmidt, Kristina; Sekul, Renate; Hilbrig, Frank; Ludolph, Heiko; Freitag, Ruth
Antibody purification by affinity chromatography based on small molecule affinity ligands ident ...
in Journal of Chromatography A volume 1218 (2011) issue 29. - page 4649-4659
doi:10.1016/j.chroma.2011.05.040 ...

Schallon, Anja; Synatschke, Christopher V.; Pergushov, Dmitry V.; Jérôme, Valérie; Müller, Axel H. E.; Freitag, Ruth
DNA Melting Temperature Assay for Assessing the Stability of DNA Polyplexes Intended for Nonvir ...
in Langmuir volume 27 (2011) issue 19. - page 12042-12051
doi:10.1021/la201803c ...

Synatschke, Christopher V.; Schallon, Anja; Jérôme, Valérie; Freitag, Ruth; Müller, Axel H. E.
Influence of Polymer Architecture and Molecular Weight of Poly(2-(dimethylamino)ethyl methacryl ...
in Biomacromolecules volume 12 (2011) issue 12. - page 4247-4255
doi:10.1021/bm201111d ...

Pfaff, André; Schallon, Anja; Ruhland, Thomas M.; Majewski, Alexander P.; Schmalz, Holger; Freitag, Ruth; Müller, Axel H. E.
Magnetic and Fluorescent Glycopolymer Hybrid Nanoparticles for Intranuclear Optical Imaging
in Biomacromolecules volume 12 (2011) issue 10. - page 3805-3811
doi:10.1021/bm201051p ...

2010

Jung, Christoph; Polier, Sigrun; Schöffel, Markus; Drechsler, Markus; Jérôme, Valérie; Freitag, Ruth
Fluorescence Correlation Spectroscopy as a Quantitative Tool Applied to Drug Delivery Model Sys ...
in Nature Precedings (2010)
doi:10.1038/npre.2010.4140.1 ...

Müllner, Markus; Schallon, Anja; Walther, Andreas; Freitag, Ruth; Müller, Axel H. E.
Clickable, Biocompatible, and Fluorescent Hybrid Nanoparticles for Intracellular Delivery and O ...
in Biomacromolecules volume 11 (2010) issue 2. - page 390-396
doi:10.1021/bm901099p ...

Freimark, Denise; Jérôme, Valérie; Freitag, Ruth
A GFP-based method facilitates clonal selection of transfected CHO cells
in Biotechnology Journal volume 5 (2010) issue 1. - page 24-31
doi:10.1002/biot.200800264 ...

2009

Hofstetter, Eugen-Maria; Gabler, Ralf; Peiffer, Stefan; Hilbrig, Frank; Freitag, Ruth
Ammoniakstrippung an einer etablierten, thermophilen Biogasanlage - technische und wirtschaftli ...
in Chemie Ingenieur Technik volume 81 (2009) issue 7. - page 921-932
doi:10.1002/cite.200900033 ...

Jérôme, Valérie; Heider, Andreas; Schallon, Anja; Freitag, Ruth
Exhaustive in vivo labelling of plasmid DNA with BrdU for intracellular detection in non-viral ...
in Biotechnology Journal volume 4 (2009) issue 10. - page 1479-1487
doi:10.1002/biot.200900053 ...

Weiss, Agnes; Jérôme, Valérie; Burghardt, Diana; Likke, Likke; Peiffer, Stefan; Hofstetter, Eugen-Maria; Gabler, Ralf; Freitag, Ruth
Investigation of factors influencing biogas production in a large-scale thermophilic municipal ...
in Applied Microbiology and Biotechnology volume 84 (2009) issue 5. - page 987-1001
doi:10.1007/s00253-009-2093-6 ...

Schubert, Sven; Freitag, Ruth
Investigation of the interaction mechanism of the recombinant human antibody MDJ8 and its fragm ...
in Journal of Chromatography A volume 1216 (2009) issue 18. - page 3831-3840
doi:10.1016/j.chroma.2009.02.074 ...

Hilbrig, Frank; Jérôme, Valérie; Salzig, Mark; Freitag, Ruth
Strategy for the isolation of native dehydrogenases with potential for biosensor development fr ...
in Journal of Chromatography A volume 1216 (2009) issue 16. - page 3518-3525
doi:10.1016/j.chroma.2008.09.020 ...

Parisot, Judicaël; Kurz, Katrin; Hilbrig, Frank; Freitag, Ruth
Use of azobenzene amino acids as photo-responsive conformational switches to regulate antibody– ...
in Journal of Separation Science volume 32 (2009) issue 10. - page 1613-1624
doi:10.1002/jssc.200800698 ...

2008

Achmann, Sabine; Hermann, Markus; Hilbrig, Frank; Jérôme, Valérie; Hämmerle, Martin; Freitag, Ruth; Moos, Ralf
Direct detection of formaldehyde in air by a Novel NAD⁺- and glutathione-independent formaldehy ...
in Talanta volume 75 (2008) issue 3. - page 786-791
doi:10.1016/j.talanta.2007.12.015 ...

Weiss, Agnes; Jérôme, Valérie; Freitag, Ruth; Mayer, Helmut K.
Diversity of the resident microbiota in a thermophilic municipal biogas plant
in Applied Microbiology and Biotechnology volume 81 (2008) issue 1. - page 163-173
doi:10.1007/s00253-008-1717-6 ...

Stocker-Majd, Gisela; Hilbrig, Frank; Freitag, Ruth
Extraction of haemoglobin from human blood by affinity precipitation using a haptoglobin-based ...
in Journal of Chromatography A volume 1194 (2008) issue 1. - page 57-65
doi:10.1016/j.chroma.2008.03.091 ...

Stocker, Gisela; Dumoulin, Dorothée; Vandevyver, Caroline; Hilbrig, Frank; Freitag, Ruth
Screening of a human antibody phage display library against a peptide antigen using stimuli-res ...
in Biotechnology Progress volume 24 (2008) issue 6. - page 1314-1324
doi:10.1002/btpr.60 ...

Freitag, Ruth; Hilbrig, Frank
Use of the avidin (imino)biotin system as a general approach to affinity precipitation
Avidin-Biotin interactions : methods and applications
Totowa, NJ : Humana Press, 2008. - page 35-50 . - (Methods in Molecular Biology; 418)

2007

Freitag, Ruth; Schumacher, Ivo; Hilbrig, Frank
Affinity precipitation an option for early capture in bioprocessing
in Biotechnology Journal volume 2 (2007) issue 6. - page 685-690
doi:10.1002/biot.200600200 ...

Willert-Porada, Monika; Lorenz, Katrin; Freitag, Ruth; Jérôme, Valérie; Pfeiffer, Stefan
Biofilm Based Microbial Fuel Cell
NSTI Nanotech 2007
Boston, Mass. : Nano Science and Technology Institute, 2007. - page 728-731
http://www.nsti.org/publications/Nanotech/2007/pdf ...

Schubert, Sven; Freitag, Ruth
Comparison of ceramic hydroxy- and fluoroapatite versus Protein A/G-based resins in the isolati ...
in Journal of Chromatography A volume 1142 (2007) issue 1. - page 106-113
doi:10.1016/j.chroma.2006.08.075 ...

Weiss, Agnes; Jérôme, Valérie; Freitag, Ruth
Comparison of strategies for the isolation of PCR-compatible, genomic DNA from a municipal biog ...
in Journal of Chromatography B volume 853 (2007) issue 1-2. - page 190-197
doi:10.1016/j.jchromb.2007.03.009 ...

Jérôme, Valérie; Hermann, Markus; Hilbrig, Frank; Freitag, Ruth
Development of a fed-batch process for the production of a dye-linked formaldehyde dehydrogenas ...
in Applied Microbiology and Biotechnology volume 77 (2007) issue 4. - page 779-788
doi:10.1007/s00253-007-1218-z ...

O'Mahony, Kevin; Freitag, Ruth; Hilbrig, Frank; Schumacher, Ingo; Müller, Patrick
Integration of bacteria capture via filtration and in situ lysis for recovery of plasmid DNA un ...
in Biotechnology Progress volume 23 (2007) issue 4. - page 895-903
doi:10.1021/bp0701113 ...

Vandevyver, Caroline; Canarelli, Stéphane; Bossen, Claudia; Fisch, Igor; Motmans, Kris; Raus, Jef; Freitag, Ruth
Investigation and molecular mimicry of the antigen involved in the interaction between the mono ...
in Biotechnology and Bioengineering volume 97 (2007) issue 4. - page 721-734
doi:10.1002/bit.21276 ...

Achmann, Sabine; Hermann, Markus; Jérôme, Valérie; Hämmerle, Martin; Freitag, Ruth; Moos, Ralf
NAD-unabhängige Formaldehyddehydrogenase aus H. zavarzinii : Einsatz im Biosensor
2007
5. Deutsches Biosensor Symposium 2007, Bochum, Deutschland

Freitag, Ruth; Hilbrig, Frank
Theory and practical understanding of the migration behavior of proteins and peptides in CE and ...
in Electrophoresis volume 28 (2007) issue 13. - page 2125-2144
doi:10.1002/elps.200600792 ...

2006

O'Mahony, Kevin; Freitag, Ruth; Dhote, Bernhard; Hilbrig, Frank; Müller, Patrick; Schumacher, Ivo
Capture of Bacteria from Fermentation Broth by Body Feed Filtration : A Solved Problem?
in Biotechnology Progress volume 22 (2006) issue 2. - page 471-483
doi:10.1021/bp050302a ...

Pöhner, Claudia; Hilbrig, Frank; Jérôme, Valérie; Freitag, Ruth
Design and Characterization of Stimuli-Responsive FLAG-tag Analogues and the Illumination-Induc ...
in Biotechnology Progress volume 22 (2006) issue 4. - page 1170-1178
doi:10.1021/bp060011h ...

Stocker, Gisela; Vandevyver, Caroline; Hilbrig, Frank; Freitag, Ruth
Purification of RT-PCR Competent Poly(A) mRNA from Crude Cell Lysate by Affinity Precipitation
in Biotechnology Progress volume 22 (2006) issue 6. - page 1621-1629
doi:10.1021/bp060095u ...

2005

Jozwik, Magdalena; Kaczmarski, Krzystof; Freitag, Ruth
Investigation of the steric mass action formalism in the simulation of breakthrough curves on a ...
in Journal of Chromatography A volume 1073 (2005) issue 1-2. - page 111-121
doi:10.1016/j.chroma.2005.01.059 ...

Desponds, Arnaud; Freitag, Ruth
Light-responsive bioconjugates as novel tools for specific capture of biologicals by photoaffin ...
in Biotechnology and Bioengineering volume 91 (2005) issue 5. - page 583-591
doi:10.1002/bit.20479 ...

O'Mahony, Kevin; Freitag, Ruth; Hilbrig, Frank; Müller, Patrick; Schumacher, Ivo
Proposal for a better integration of bacterial lysis into the production of plasmid DNA at larg ...
in Journal of Biotechnology volume 119 (2005) issue 2. - page 118-132
doi:10.1016/j.jbiotec.2005.03.020 ...

Yamahata, Christophe; Vandevyver, Caroline; Lacharme, Frederic; Izewska, Paulina; Vogel, Horst; Freitag, Ruth; Gijs, Martin A. M.
Pumping of mammalian cells with a nozzle-diffuser micropump
in Lab on a Chip volume 5 (2005) issue 10. - page 1083-1088
doi:10.1039/B504468E ...

Suarez, Mougli; Haenni, Marisa; Canarelli, Stéphane; Fisch, Florian; Chodanowski, Pierre; Servis, Catherine; Michielin, Olivier; Freitag, Ruth; Moreillon, Philippe; Mermod, Nicolas
Structure-Function Characterization and Optimization of a Plant-Derived Antibacterial Peptide
in Antimicrobial Agents and Chemotherapy volume 49 (2005) issue 9. - page 3847-3857
doi:10.1128/AAC.49.9.3847-3857.2005 ...

Szekely, Laszlo; Freitag, Ruth
Study of the electroosmotic flow as a means to propel the mobile phase in capillary electrochro ...
in Electrophoresis volume 26 (2005) issue 10. - page 1928-1939
doi:10.1002/elps.200410194 ...

2004

Malinova, Vesela; Freitag, Ruth; Wandrey, Christine
Adsorption of charged macromolecules on oppositely charged porous column materials
in Journal of Chromatography A volume 1036 (2004) issue 1. - page 25-32
doi:10.1016/j.chroma.2003.10.087 ...

Szucs, Veronika; Freitag, Ruth
Comparison of a three-peptide separation by capillary electrochromatography, voltage-assisted l ...
in Journal of Chromatography A volume 1044 (2004) issue 1-2. - page 201-210
doi:10.1016/j.chroma.2004.05.103 ...

Freitag, Ruth
Comparison of the chromatographic behavior of monolithic capillary columns in capillary electro ...
in Journal of Chromatography A volume 1033 (2004) issue 2. - page 267-273
doi:10.1016/j.chroma.2004.01.053 ...

Leiderer, M.; Ponader, Thomas; Schumacher, Matthias; Lauterbach, Anja; Hilgert, Karin; Hermann, Markus; Jérôme, Valérie; Hämmerle, Martin; Moos, Ralf; Freitag, Ruth
Elektrochemischer Enzym-Biosensor zur Detektion von gasförmigem Formaldehyd
2004
DECHEMA/GVC-Jahrestagung 2004, Karlsruhe

Lauterbach, Anja; Leiderer, M.; Ponader, P.; Schumacher, Matthias; Hämmerle, Martin; Moos, Ralf; Hermann, Markus; Jérôme, Valérie; Freitag, Ruth
Untersuchungen einer 'Dye-linked' Formaldehyddehydrogenase aus methylotrophen Bakterien
2004
BioPerspectives 2004, Wiesbaden, Deutschland

Jess, Andreas; Freitag, Ruth
Verfahren und Prozesse - nicht nur vor Gericht
in Spektrum (2004) issue 2. - page 28-31
http://www.neu.uni-bayreuth.de/de/Uni_Bayreuth/Sta ...

2003

Hilbrig, Frank; Freitag, Ruth
Continuous annular chromatography
in Journal of Chromatography B volume 790 (2003) issue 1-2. - page 1-15
doi:10.1016/S1570-0232(03)00085-0 ...

Costioli, Matteo D.; Fisch, Igor; Garret-Flaudy, Frédéric; Hilbrig, Frank; Freitag, Ruth
DNA purification by triple-helix affinity precipitation
in Biotechnology and Bioengineering volume 81 (2003) issue 5. - page 535-545
doi:10.1002/bit.10497 ...

Hoegger, Daniela; Freitag, Ruth
Investigation of conditions allowing the synthesis of acrylamide-based monolithic microcolumns ...
in Electrophoresis volume 24 (2003) issue 17. - page 2958-2972
doi:10.1002/elps.200305522 ...

Hoegger, Daniela; Freitag, Ruth
Investigation of mixed-mode monolithic stationary phases for the analysis of charged amino acid ...
in Journal of Chromatography A volume 1004 (2003) issue 1-2. - page 195-208
doi:10.1016/S0021-9673(03)00563-6 ...

Schmidt, Beata; Wandrey, Christine; Freitag, Ruth
Investigation of particle-based and monolithic columns for cation exchange protein displacement ...
in Journal of Chromatography A volume 1018 (2003) issue 2. - page 155-167
doi:10.1016/S0021-9673(03)01326-8 ...

Hilbrig, Frank; Freitag, Ruth
Protein purification by affinity precipitation
in Journal of Chromatography B volume 790 (2003) issue 1-2. - page 79-90
doi:10.1016/S1570-0232(03)00081-3 ...

2002

Giovannini, Roberto; Freitag, Ruth
Continuous Separation of Multicomponent Protein Mixtures by Annular Displacement Chromatography
in Biotechnology Progress volume 18 (2002) issue 6. - page 1324-1331
doi:10.1021/bp010154y ...

Canarelli, Stéphane; Fisch, Igor; Freitag, Ruth
Hyphenation of multi-dimensional chromatography and mass spectrometry for the at-line-analysis ...
in Journal of Chromatography B volume 775 (2002) issue 1. - page 27-35
doi:10.1016/S1570-0232(02)00286-6 ...

2001

Garret-Flaudy, Frédéric; Freitag, Ruth
Use of the avidin (imino)biotin system as a general approach to affinity precipitation
in Biotechnology and Bioengineering volume 71 (2001) issue 3. - page 223-234
doi:10.1002/1097-0290(2000)71:3<223::AID-BIT1012>3 ...

Prof. Dr. Ruth Freitag

Faculty of Engineering Science
Chair for Process Biotechnology


Prof. Dr. Ruth Freitag

Department of Engineering Science

University of Bayreuth
Universitätsstraße 30
D-95447 Bayreuth

Phone: +49 (0)921 / 55-7370
E-mail: bioprozesstechnik@uni-bayreuth.de
Homepage: Chair for Process Biotechnology

Webmaster: Univ.Prof.Dr. Hans-Werner Schmidt

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