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Prof. Dr. Ruth Freitag

Prof. Dr. Ruth Freitag

Fakultät für Ingenieurwissenschaften
Lehrstuhlinhaberin Bioprozesstechnik


Ausgewählte Publikationen

2024

Steiner, Thomas; Leitner, Lisa-Cathrin; Zhang, Yuanhu; Möller, Julia N.; Löder, Martin G. J.; Greiner, Andreas; Laforsch, Christian; Freitag, Ruth
Detection and specific chemical identification of submillimeter plastic fragments in complex ma ...
In: Scientific Reports Bd. 14 (2024)
doi:10.1038/s41598-024-51185-6 ...

Jasinski, Julia; Völkl, Matthias; Wilde, Magdalena V.; Jérôme, Valérie; Fröhlich, Thomas; Freitag, Ruth; Scheibel, Thomas
Influence of the polymer type of a microplastic challenge on the reaction of murine cells
In: Journal of Hazardous Materials Bd. 465 (2024)
doi:10.1016/j.jhazmat.2023.133280 ...

Mondellini, Simona; Schwarzer, Michael; Völkl, Matthias; Jasinski, Julia; Jérôme, Valérie; Scheibel, Thomas; Laforsch, Christian; Freitag, Ruth
Size dependent uptake and trophic transfer of polystyrene microplastics in unicellular freshwat ...
In: Science of the Total Environment Bd. 929 (2024)
doi:10.1016/j.scitotenv.2024.172470 ...

2023

Helm, Moritz; Huang, Songyan Ben; Gollner, Katrin; Gollner, Ulrich; Jérôme, Valérie; Freitag, Ruth
Cultivation of Encapsulated Primary Human B Lymphocytes : A First Step toward a Bioartificial G ...
In: Macromolecular Bioscience Bd. 23 (2023) Heft 1
doi:10.1002/mabi.202200256 ...

Leitner, Lisa-Cathrin; Schneider, Rika; Steiner, Thomas; Stenzel, Martina H.; Freitag, Ruth; Greiner, Andreas
Efficient Synthesis and Wetting Characteristics of Amphiphilic Galactose-PLA Block Copolymers : ...
In: Macromolecular Chemistry and Physics Bd. 224 (2023) Heft 1
doi:10.1002/macp.202100431 ...

Steiner, Thomas; Möller, Julia N.; Löder, Martin G. J.; Hilbrig, Frank; Laforsch, Christian; Freitag, Ruth
Microplastic Contamination of Composts and Liquid Fertilizers from Municipal Biowaste Treatment ...
In: Waste and Biomass Valorization Bd. 14 (2023) . - S. 873-887
doi:10.1007/s12649-022-01870-2 ...

Jasinski, Julia; Völkl, Matthias; Hahn, Jonas; Jérôme, Valérie; Freitag, Ruth; Scheibel, Thomas
Polystyrene microparticle distribution after ingestion by murine macrophages
In: Journal of Hazardous Materials Bd. 457 (2023)
doi:10.1016/j.jhazmat.2023.131796 ...

Zhang, Yuanhu; Paul, Tasmai; Brehm, Julian; Völkl, Matthias; Jérôme, Valérie; Freitag, Ruth; Laforsch, Christian; Greiner, Andreas
Role of Residual Monomers in the Manifestation of (Cyto)toxicity by Polystyrene Microplastic Mo ...
In: Environmental Science & Technology Bd. 57 (2023) Heft 27. - S. 9925-9933
doi:10.1021/acs.est.3c01134 ...

Xu, Chengzhang; Cheong, Jun Young; Mo, Xiumei; Jérôme, Valérie; Freitag, Ruth; Agarwal, Seema; Gharibi, Reza; Greiner, Andreas
Thoroughly Hydrophilized Electrospun Poly(L-Lactide)/ Poly(ε-Caprolactone) Sponges for Tissue E ...
In: Macromolecular Bioscience Bd. 23 (2023) Heft 11
doi:10.1002/mabi.202300143 ...

2022

Müller, Ann-Kathrin; Brehm, Julian; Völkl, Matthias; Jérôme, Valérie; Laforsch, Christian; Freitag, Ruth; Greiner, Andreas
Disentangling biological effects of primary nanoplastics from dispersion paints' additional com ...
In: Ecotoxicology and Environmental Safety Bd. 242 (2022)
doi:10.1016/j.ecoenv.2022.113877 ...

Simeon, Meshack Imologie; Herkendell, Katharina; Pant, Deepak; Freitag, Ruth
Electrochemical evaluation of different polymer binders for the production of carbon-modified s ...
In: Chemical Engineering Journal Advances Bd. 10 (2022)
doi:10.1016/j.ceja.2022.100246 ...

Liao, Xiaojian; Jérôme, Valérie; Agarwal, Seema; Freitag, Ruth; Greiner, Andreas
High Strength and High Toughness Electrospun Multifibrillar Yarns with Highly Aligned Hierarchy ...
In: Macromolecular Bioscience Bd. 22 (2022) Heft 12
doi:10.1002/mabi.202200291 ...

Riedl, Simon; Völkl, Matthias; Holzinger, Anja; Jasinski, Julia; Jérôme, Valérie; Scheibel, Thomas; Feldhaar, Heike; Freitag, Ruth
In vitro cultivation of primary intestinal cells from Eisenia fetida as basis for ecotoxicologi ...
In: Ecotoxicology Bd. 31 (2022) . - S. 221-233
doi:10.1007/s10646-021-02495-2 ...

Simeon, Meshack Imologie; Freitag, Ruth
Influence of electrode spacing and fed-batch operation on the maximum performance trend of a so ...
In: International Journal of Hydrogen Energy Bd. 47 (2022) Heft 24. - S. 12304-12316
doi:10.1016/j.ijhydene.2021.11.110 ...

Mlinar, Stanislava; Weig, Alfons; Freitag, Ruth
Influence of NH₃ and NH₄⁺ on anaerobic digestion and microbial population structure at increasi ...
In: Bioresource Technology Bd. 361 (2022)
doi:10.1016/j.biortech.2022.127638 ...

Schöpfer, Lion; Möller, Julia N.; Steiner, Thomas; Schnepf, Uwe; Marhan, Sven; Resch, Julia; Bayha, Ansilla; Löder, Martin G. J.; Freitag, Ruth; Brümmer, Franz; Laforsch, Christian; Streck, Thilo; Forberger, Jens; Kranert, Martin; Kandeler, Ellen; Pagel, Holger
Microplastics persist in an arable soil but do not affect soil microbial biomass, enzyme activi ...
In: Journal of Plant Nutrition and Soil Science Bd. 185 (2022) Heft 6. - S. 836-849
doi:10.1002/jpln.202200062 ...

Steiner, Thomas; Zhang, Yuanhu; Möller, Julia N.; Agarwal, Seema; Löder, Martin G. J.; Greiner, Andreas; Laforsch, Christian; Freitag, Ruth
Municipal biowaste treatment plants contribute to the contamination of the environment with res ...
In: Scientific Reports Bd. 12 (2022)
doi:10.1038/s41598-022-12912-z ...

Simeon, Meshack Imologie; Weig, Alfons; Freitag, Ruth
Optimization of soil microbial fuel cell for sustainable bio-electricity production: combined e ...
In: Biotechnology for Biofuels and Bioproducts Bd. 15 (2022)
doi:10.1186/s13068-022-02224-9 ...

Riedl, Simon; Jérôme, Valérie; Freitag, Ruth
Repeated Transient Transfection : An Alternative for the Recombinant Production of Difficult-to ...
In: Processes Bd. 10 (2022) Heft 6
doi:10.3390/pr10061064 ...

Ramsperger, Anja; Jasinski, Julia; Völkl, Matthias; Witzmann, Thomas; Meinhart, Marcel; Jérôme, Valérie; Kretschmer, Winfried; Freitag, Ruth; Senker, Jürgen; Fery, Andreas; Kress, Holger; Scheibel, Thomas; Laforsch, Christian
Supposedly identical microplastic particles substantially differ in their material properties i ...
In: Journal of Hazardous Materials Bd. 425 (2022)
doi:10.1016/j.jhazmat.2021.127961 ...

Jasinski, Julia; Wilde, Magdalena V.; Völkl, Matthias; Jérôme, Valérie; Fröhlich, Thomas; Freitag, Ruth; Scheibel, Thomas
Tailor-Made Protein Corona Formation on Polystyrene Microparticles and its Effect on Epithelial ...
In: ACS Applied Materials & Interfaces Bd. 14 (2022) Heft 41. - S. 47277-47287
doi:10.1021/acsami.2c13987 ...

Völkl, Matthias; Jérôme, Valérie; Weig, Alfons; Jasinski, Julia; Meides, Nora; Strohriegl, Peter; Scheibel, Thomas; Freitag, Ruth
Pristine and artificially-aged polystyrene microplastic particles differ in regard to cellular ...
In: Journal of Hazardous Materials Bd. 435 (2022)
doi:10.1016/j.jhazmat.2022.128955 ...

Riese, Cornelius N.; Wittchen, Manuel; Jérôme, Valérie; Freitag, Ruth; Busche, Tobias; Kalinowski, Jörn; Schüler, Dirk
The transcriptomic landscape of Magnetospirillum gryphiswaldense during magnetosome biominerali ...
In: BMC Genomics Bd. 23 (2022)
doi:10.1186/s12864-022-08913-x ...

2021

Diaz Ariza, Ivonne L.; Jérôme, Valérie; Pérez Pérez, León D.; Freitag, Ruth
Amphiphilic Graft Copolymers Capable of Mixed-Mode Interaction as Alternative Nonviral Transfec ...
In: ACS Applied Bio Materials Bd. 4 (2021) Heft 2. - S. 1268-1282
doi:10.1021/acsabm.0c01123 ...

Simeon, Meshack Imologie; Imoize, Agbotiname Lucky; Freitag, Ruth
Comparative evaluation of the performance of a capacitive and a non-capacitive microbial fuel c ...
18th International Multi-Conference on Systems, Signals & Devices (SSD 2021)
Piscataway, NJ : IEEE, 2021. - S. 1076-1082
doi:10.1109/SSD52085.2021.9429481 ...

Diaz, Ivonne L.; Jérôme, Valérie; Freitag, Ruth; Perez, León D.
Development of poly(ethyleneimine) grafted amphiphilic copolymers : Evaluation of their cytotox ...
In: Journal of Bioactive and Compatible Polymers Bd. 36 (2021) Heft 6. - S. 447-463
doi:10.1177/08839115211053925 ...

Keim, Daniel; Gollner, Katrin; Gollner, Ulrich; Jérôme, Valérie; Freitag, Ruth
Generation of Recombinant Primary Human B Lymphocytes Using Non-Viral Vectors
In: International Journal of Molecular Sciences Bd. 22 (2021) Heft 15
doi:10.3390/ijms22158239 ...

Helm, Moritz; Riedl, Simon; Gollner, Katrin; Gollner, Ulrich; Jérôme, Valérie; Freitag, Ruth
Isolation of primary human B lymphocytes from tonsils compared to blood as alternative source f ...
In: Journal of Chromatography B Bd. 1179 (2021)
doi:10.1016/j.jchromb.2021.122853 ...

Rudolph, Julia; Völkl, Matthias; Jérôme, Valérie; Scheibel, Thomas; Freitag, Ruth
Noxic effects of polystyrene microparticles on murine macrophages and epithelial cells
In: Scientific Reports Bd. 11 (2021)
doi:10.1038/s41598-021-95073-9 ...

Rosenfeldt, Sabine; Mickoleit, Frank; Jörke, Cornelia; Clement, Joachim H.; Markert, Simon; Jérôme, Valérie; Schwarzinger, Stephan; Freitag, Ruth; Schüler, Dirk; Uebe, René; Schenk, Anna
Towards standardized purification of bacterial magnetic nanoparticles for future in vivo applic ...
In: Acta Biomaterialia Bd. 120 (2021) . - S. 293-303
doi:10.1016/j.actbio.2020.07.042 ...

Weithmann, Nicolas; Mlinar, Stanislava; Sonnleitner, Eva; Weig, Alfons; Freitag, Ruth
Flexible feeding in anaerobic digestion : Impact on process stability, performance and microbia ...
In: Anaerobe Bd. 68 (2021)
doi:10.1016/j.anaerobe.2020.102297 ...

2020

Riese, Cornelius N.; Uebe, René; Rosenfeldt, Sabine; Schenk, Anna; Jérôme, Valérie; Freitag, Ruth; Schüler, Dirk
An automated oxystat fermentation regime for microoxic cultivation of Magnetospirillum gryphisw ...
In: Microbial Cell Factories Bd. 19 (2020)
doi:10.1186/s12934-020-01469-z ...

Mickoleit, Frank; Jérôme, Valérie; Freitag, Ruth; Schüler, Dirk
Bacterial Magnetosomes as Novel Platform for the Presentation of Immunostimulatory, Membrane-Bo ...
In: Advanced Biosystems Bd. 4 (2020) Heft 3
doi:10.1002/adbi.201900231 ...

Mlinar, Stanislava; Weig, Alfons; Freitag, Ruth
Influence of mixing and sludge volume on stability, reproducibility, and productivity of labora ...
In: Bioresource Technology Reports Bd. 11 (2020)
doi:10.1016/j.biteb.2020.100444 ...

Mader, Michael; Helm, Moritz; Lu, Mingxia; Stenzel, Martina H.; Jérôme, Valérie; Agarwal, Seema; Freitag, Ruth; Greiner, Andreas
Perfusion Cultivation of Artificial Liver ECM in Fibrous Polymer Sponges Biomimicking Scaffolds ...
In: Biomacromolecules Bd. 21 (2020) Heft 10. - S. 4094-4104
doi:10.1021/acs.biomac.0c00900 ...

Simeon, Meshack Imologie; Asoiro, Felix U.; Aliyu, Mohamad; Raji, Olayinka A.; Freitag, Ruth
Polarization and power density trends of a soil-based microbial fuel cell treated with human ur ...
In: International Journal of Energy Research Bd. 44 (2020) Heft 7. - S. 5968-5976
doi:10.15495/EPub_UBT_00005040 ...

Diaz, Ivonne L.; Sierra, Cesar A.; Jérôme, Valérie; Freitag, Ruth; Perez, León D.
Target grafting of poly(2-(dimethylamino)ethyl methacrylate) to biodegradable block copolymers
In: Journal of Polymer Science Bd. 58 (2020) Heft 16. - S. 2168-2180
doi:10.1002/pol.20200204 ...

Jérôme, Valérie; Synatschke, Christopher V.; Freitag, Ruth
Transient Destabilization of Biological Membranes Contributes to the Superior Performance of St ...
In: ACS Omega Bd. 5 (2020) Heft 41. - S. 26640-26654
doi:10.1021/acsomega.0c03367 ...

2019

Weithmann, Nicolas; Mlinar, Stanislava; Hilbrig, Frank; Bachmaf, Samer; Arndt, Julia; Planer-Friedrich, Britta; Weig, Alfons; Freitag, Ruth
Arsenic metabolism in technical biogas plants : possible consequences for resident microbiota a ...
In: AMB Express Bd. 9 (2019)
doi:10.1186/s13568-019-0902-6 ...

Reich, Steffen; Kaiser, Patrick; Mafi, Mahsa; Schmalz, Holger; Rhinow, Daniel; Freitag, Ruth; Greiner, Andreas
High‐Temperature Spray‐Dried Polymer/Bacteria Microparticles for Electrospinning of Composite N ...
In: Macromolecular Bioscience Bd. 19 (2019) Heft 5
doi:10.1002/mabi.201800356 ...

Jérôme, Valérie; Freitag, Ruth; Schüler, Dirk; Mickoleit, Frank
SEAP activity measurement in reporter cell-based assays using BCIP / NBT as substrate
In: Analytical Biochemistry Bd. 585 (2019)
doi:10.1016/j.ab.2019.113402 ...

2018

Chen, Baizhu; Synatschke, Christopher V.; Jérôme, Valérie; Müller, Axel H. E.; Freitag, Ruth; Wu, Chi
Co-transfection of star-shaped PDMAEMAs enhance transfection efficiency of protamine/pDNA compl ...
In: European Polymer Journal Bd. 103 (2018) . - S. 362-369
doi:10.1016/j.eurpolymj.2018.04.022 ...

Riedl, Simon; Kaiser, Patrick; Raup, Alexander; Synatschke, Christopher V.; Jérôme, Valérie; Freitag, Ruth
Non-Viral Transfection of Human T Lymphocytes
In: Processes Bd. 6 (2018) Heft 10
doi:10.3390/pr6100188 ...

Stoppok, Manfred; Jess, Andreas; Freitag, Ruth; Alber, Erdmute
Of culture, consumption and cost : A comparative Analysis of household energy consumption in Ke ...
In: Energy Research & Social Science Bd. 40 (2018) . - S. 127-139
doi:10.1016/j.erss.2017.12.004 ...

Weithmann, Nicolas; Möller, Julia N.; Löder, Martin G. J.; Piehl, Sarah; Laforsch, Christian; Freitag, Ruth
Organic fertilizer as a vehicle for the entry of microplastic into the environment
In: Science Advances Bd. 4 (2018) Heft 4
doi:10.1126/sciadv.aap8060 ...

Pretscher, Martin; Pineda-Contreras, Beatriz A.; Kaiser, Patrick; Reich, Steffen; Schöbel, Judith; Kuttner, Christian; Freitag, Ruth; Fery, Andreas; Schmalz, Holger; Agarwal, Seema
pH-Responsive Biohybrid Carrier Material for Phenol Decontamination in Wastewater
In: Biomacromolecules Bd. 19 (2018) Heft 8. - S. 3224-3232
doi:10.1021/acs.biomac.8b00361 ...

Kaiser, Patrick; Reich, Steffen; Greiner, Andreas; Freitag, Ruth
Preparation of Biocomposite Microfibers Ready for Processing into Biologically Active Textile F ...
In: Macromolecular Bioscience Bd. 18 (2018) Heft 7
doi:10.1002/mabi.201800046 ...

Kaiser, Patrick; Werner, Melanie; Jérôme, Valérie; Freitag, Ruth
Scale‐up of the ex vivo expansion of encapsulated primary human T lymphocytes
In: Biotechnology and Bioengineering Bd. 115 (2018) Heft 10. - S. 2632-2642
doi:10.1002/bit.26786 ...

Mader, Michael; Jérôme, Valérie; Freitag, Ruth; Agarwal, Seema; Greiner, Andreas
Ultraporous, compressible, wettable polylactide/polycaprolactone sponges for tissue engineering
In: Biomacromolecules Bd. 19 (2018) Heft 5. - S. 1663-1673
doi:10.1021/acs.biomac.8b00434 ...

2017

Raup, Alexander; Wang, Hui; Synatschke, Christopher V.; Jérôme, Valérie; Agarwal, Seema; Pergushov, Dmitry V.; Müller, Axel H. E.; Freitag, Ruth
Compaction and transmembrane delivery of pDNA : differences between l-PEI and two types of amph ...
In: Biomacromolecules Bd. 18 (2017) Heft 3. - S. 808-818
doi:10.1021/acs.biomac.6b01678 ...

Jérôme, Valérie; Thoring, Lena; Salzig, Denise; Kubick, Stefan; Freitag, Ruth
Comparison of cell-based versus cell-free mammalian systems for the production of a recombinant ...
In: Engineering in Life Sciences Bd. 17 (2017) Heft 10. - S. 1097-1107
doi:10.1002/elsc.201700005 ...

Jérôme, Valérie; Werner, Melanie; Kaiser, Patrick; Freitag, Ruth
Creating a Biomimetic Microenvironment for the Ex Vivo Expansion of Primary Human T Lymphocytes
In: Macromolecular Bioscience Bd. 17 (2017) Heft 9
doi:10.1002/mabi.201700091 ...

Kaiser, Patrick; Reich, Steffen; Leykam, Daniel; Willert-Porada, Monika; Greiner, Andreas; Freitag, Ruth
Electrogenic Single-Species Biocomposites as Anodes for Microbial Fuel Cells
In: Macromolecular Bioscience Bd. 17 (2017) Heft 7
doi:10.1002/mabi.201600442 ...

Stahlschmidt, Ullrich; Jérôme, Valérie; Majewski, Alexander P.; Müller, Axel H. E.; Freitag, Ruth
Systematic Study of a Library of PDMAEMA-Based, Superparamagnetic Nano-Stars for the Transfecti ...
In: Polymers Bd. 9 (2017) Heft 5
doi:10.3390/polym9050156 ...

2016

Raup, Alexander; Stahlschmidt, Ullrich; Jérôme, Valérie; Synatschke, Christopher V.; Müller, Axel H. E.; Freitag, Ruth
Influence of Polyplex Formation on the Performance of Star-Shaped Polycationic Transfection Agen ...
In: Polymers Bd. 8 (2016) Heft 6
doi:10.3390/polym8060224 ...

Weithmann, Nicolas; Weig, Alfons; Freitag, Ruth
Process parameters and changes in the microbial community patterns during the first 240 days of ...
In: AMB Express Bd. 6 (2016)
doi:10.1186/s13568-016-0219-7 ...

Zambrano, Kenny; Jérôme, Valérie; Freitag, Ruth; Buchholz, Rainer; Jäck, Hans-Martin; Hübner, Holger; Schuh, Wolfgang
Prolonged Ex vivo expansion and differentiation of naïve murine CD43− B splenocytes
In: Biotechnology Progress Bd. 32 (2016) Heft 4. - S. 978-989
doi:10.1002/btpr.2265 ...

Raup, Alexander; Jérôme, Valérie; Freitag, Ruth; Synatschke, Christopher V.; Müller, Axel H. E.
Promoter, transgene, and cell line effects in the transfection of mammalian cells using PDMAEMA ...
In: Biotechnology Reports Bd. 11 (2016) . - S. 53-61
doi:10.1016/j.btre.2016.05.003 ...

2015

Shi, Yinfeng; Zhou, Peiran; Jérôme, Valérie; Freitag, Ruth; Agarwal, Seema
Enzymatically Degradable Polyester-Based Adhesives
In: ACS Biomaterials Science & Engineering Bd. 1 (2015) Heft 10. - S. 971-977
doi:10.1021/acsbiomaterials.5b00217 ...

Werner, Melanie; Schmoldt, Daria; Hilbrig, Frank; Jérôme, Valérie; Raup, Alexander; Zambrano, Kenny; Hübner, Holger; Buchholz, Rainer; Freitag, Ruth
High Cell Density Cultivation of Human Leukemia T Cells (Jurkat Cells) in Semipermeable Polyele ...
In: Engineering in Life Sciences Bd. 15 (2015) Heft 4. - S. 357-367
doi:10.1002/elsc.201400186 ...

Käfer, Florian; Liu, Fangyao; Stahlschmidt, Ullrich; Jérôme, Valérie; Freitag, Ruth; Karg, Matthias; Agarwal, Seema
LCST and UCST in one : Double thermoresponsive behavior of block copolymers of poly(ethylene gl ...
In: Langmuir Bd. 31 (2015) Heft 32. - S. 8940-8946
doi:10.1021/acs.langmuir.5b02006 ...

Knierim, Christian; Enzeroth, Michaela; Kaiser, Patrick; Dams, Christian; Nette, David; Seubert, Andreas; Klingl, Andreas; Greenblatt, Charles; Jérôme, Valérie; Agarwal, Seema; Freitag, Ruth; Greiner, Andreas
Living Composites of Bacteria and Polymers as Biomimetic Films for Metal Sequestration and Bior ...
In: Macromolecular Bioscience Bd. 15 (2015) Heft 8. - S. 1052-1059
doi:10.1002/mabi.201400538 ...

Pineda Contreras, Paul; Kuttner, Christian; Fery, Andreas; Stahlschmidt, Ullrich; Jérôme, Valérie; Freitag, Ruth; Agarwal, Seema
Renaissance for Low Shrinking Resins : all-in-one Solution by Bi-Functional Vinylcyclopropane-A ...
In: Chemical Communications Bd. 51 (2015) Heft 59. - S. 11899-11902
doi:10.1039/C5CC03901K ...

Duan, Gaigai; Jiang, Shaohua; Jérôme, Valérie; Wendorff, Joachim H.; Fathi, Amir; Uhm, Jacqueline S.; Altstädt, Volker; Herling, Markus M.; Breu, Josef; Freitag, Ruth; Agarwal, Seema; Greiner, Andreas
Ultralight, Soft Polymer Sponges by Self-Assembly of Short Electrospun Fibers in Colloidal Disp ...
In: Advanced Functional Materials Bd. 25 (2015) Heft 19. - S. 2850-2856
doi:10.1002/adfm.201500001 ...

2014

Kaiser, Patrick; Werner, Melanie; Jérôme, Valérie; Hübner, Holger; Buchholz, Rainer; Freitag, Ruth
Cell Retention by Encapsulation for the Cultivation of Jurkat Cells in Fixed and Fluidized Bed ...
In: Biotechnology and Bioengineering Bd. 111 (2014) Heft 12. - S. 2571-2579
doi:10.1002/bit.25304 ...

Freitag, Ruth
Chromatographic techniques in the downstream processing of proteins in biotechnology
Animal cell biotechnology : methods and protocols
New York, NY : Humana Press, 2014. - S. 419-458 . - (Methods in Molecular Biology; 1104)
doi:10.1007/978-1-62703-733-4_25 ...

Wang, Hui; Synatschke, Christopher V.; Raup, Alexander; Jérôme, Valérie; Freitag, Ruth; Agarwal, Seema
Oligomeric dual functional antibacterial polycaprolactone
In: Polymer Chemistry Bd. 5 (2014) Heft 7. - S. 2453-2460
doi:10.1039/C3PY01467C ...

2013

Majewski, Alexander P.; Stahlschmidt, Ullrich; Jérôme, Valérie; Freitag, Ruth; Müller, Axel H. E.; Schmalz, Holger
PDMAEMA-Grafted Core-Shell-Corona Particles for Nonviral Gene Delivery and Magnetic Cell Separa ...
In: Biomacromolecules Bd. 14 (2013) Heft 9. - S. 3081-3090
doi:10.1021/bm400703d ...

Werner, Melanie; Biss, Karsten; Jérôme, Valérie; Hilbrig, Frank; Freitag, Ruth; Zambrano, Kenny; Hübner, Holger; Buchholz, Rainer; Mahou, Redouan; Wandrey, Christine
Use of the mitochondria toxicity assay for quantifying the viable cell density of microencapsul ...
In: Biotechnology Progress Bd. 29 (2013) Heft 4. - S. 986-993
doi:10.1002/btpr.1734 ...

2012

Majewski, Alexander P.; Schallon, Anja; Jérôme, Valérie; Freitag, Ruth; Müller, Axel H. E.; Schmalz, Holger
Dual-responsive magnetic core-shell nanoparticles for non-viral gene delivery and cell separati ...
In: Abstracts of Papers of the American Chemical Society Bd. 243 (2012) . - S. 40-POLY
Symposium on Ionic Liquids - Science and Applications / 243rd National Spring Meeting of the American-Chemical-Society, San Diego, CA, MAR 25-29, 2012, San Diego, CA,

Majewski, Alexander P.; Schallon, Anja; Jérôme, Valérie; Freitag, Ruth; Müller, Axel H. E.; Schmalz, Holger
Dual-Responsive Magnetic Core-Shell Nanoparticles for Nonviral Gene Delivery and Cell Separatio ...
In: Biomacromolecules Bd. 13 (2012) Heft 3. - S. 857-866
doi:10.1021/bm2017756 ...

Freimark, Denise; Jérôme, Valérie; Freitag, Ruth
Effect of process parameters and product-host-interaction on hVEGFA-production by recombinant C ...
In: Biotechnology Progress Bd. 28 (2012) Heft 3. - S. 762-772
doi:10.1002/btpr.1524 ...

Hilbrig, Frank; Freitag, Ruth
Isolation and purification of recombinant proteins, antibodies and plasmid DNA with hydroxyapat ...
In: Biotechnology Journal Bd. 7 (2012) Heft 1. - S. 90-102
doi:10.1002/biot.201100015 ...

Schallon, Anja; Synatschke, Christopher V.; Jérôme, Valérie; Müller, Axel H. E.; Freitag, Ruth
Nanoparticulate Nonviral Agent for the Effective Delivery of pDNA and siRNA to Differentiated C ...
In: Biomacromolecules Bd. 13 (2012) Heft 11. - S. 3463-3474
doi:10.1021/bm3012055 ...

Freitag, Ruth; Jérôme, Valérie; Müller, Axel H. E.; Schmalz, Holger
Polymermodifizierte magnetische Nanopartikel
In: GIT : Labor-Fachzeitschrift Bd. 56 (2012) Heft 8. - S. 602
https://www.git-labor.de/forschung/life-sciences-b ...

2011

Arnold, Marc; Bittermann, Holger; Kalbfuss-Zimmermann, Bernd; Neumann, Thomas; Schmidt, Kristina; Sekul, Renate; Hilbrig, Frank; Ludolph, Heiko; Freitag, Ruth
Antibody purification by affinity chromatography based on small molecule affinity ligands ident ...
In: Journal of Chromatography A Bd. 1218 (2011) Heft 29. - S. 4649-4659
doi:10.1016/j.chroma.2011.05.040 ...

Schallon, Anja; Synatschke, Christopher V.; Pergushov, Dmitry V.; Jérôme, Valérie; Müller, Axel H. E.; Freitag, Ruth
DNA Melting Temperature Assay for Assessing the Stability of DNA Polyplexes Intended for Nonvir ...
In: Langmuir Bd. 27 (2011) Heft 19. - S. 12042-12051
doi:10.1021/la201803c ...

Synatschke, Christopher V.; Schallon, Anja; Jérôme, Valérie; Freitag, Ruth; Müller, Axel H. E.
Influence of Polymer Architecture and Molecular Weight of Poly(2-(dimethylamino)ethyl methacryl ...
In: Biomacromolecules Bd. 12 (2011) Heft 12. - S. 4247-4255
doi:10.1021/bm201111d ...

Pfaff, André; Schallon, Anja; Ruhland, Thomas M.; Majewski, Alexander P.; Schmalz, Holger; Freitag, Ruth; Müller, Axel H. E.
Magnetic and Fluorescent Glycopolymer Hybrid Nanoparticles for Intranuclear Optical Imaging
In: Biomacromolecules Bd. 12 (2011) Heft 10. - S. 3805-3811
doi:10.1021/bm201051p ...

2010

Jung, Christoph; Polier, Sigrun; Schöffel, Markus; Drechsler, Markus; Jérôme, Valérie; Freitag, Ruth
Fluorescence Correlation Spectroscopy as a Quantitative Tool Applied to Drug Delivery Model Sys ...
In: Nature Precedings (2010)
doi:10.1038/npre.2010.4140.1 ...

Müllner, Markus; Schallon, Anja; Walther, Andreas; Freitag, Ruth; Müller, Axel H. E.
Clickable, Biocompatible, and Fluorescent Hybrid Nanoparticles for Intracellular Delivery and O ...
In: Biomacromolecules Bd. 11 (2010) Heft 2. - S. 390-396
doi:10.1021/bm901099p ...

Freimark, Denise; Jérôme, Valérie; Freitag, Ruth
A GFP-based method facilitates clonal selection of transfected CHO cells
In: Biotechnology Journal Bd. 5 (2010) Heft 1. - S. 24-31
doi:10.1002/biot.200800264 ...

2009

Hofstetter, Eugen-Maria; Gabler, Ralf; Peiffer, Stefan; Hilbrig, Frank; Freitag, Ruth
Ammoniakstrippung an einer etablierten, thermophilen Biogasanlage - technische und wirtschaftli ...
In: Chemie Ingenieur Technik Bd. 81 (2009) Heft 7. - S. 921-932
doi:10.1002/cite.200900033 ...

Jérôme, Valérie; Heider, Andreas; Schallon, Anja; Freitag, Ruth
Exhaustive in vivo labelling of plasmid DNA with BrdU for intracellular detection in non-viral ...
In: Biotechnology Journal Bd. 4 (2009) Heft 10. - S. 1479-1487
doi:10.1002/biot.200900053 ...

Weiss, Agnes; Jérôme, Valérie; Burghardt, Diana; Likke, Likke; Peiffer, Stefan; Hofstetter, Eugen-Maria; Gabler, Ralf; Freitag, Ruth
Investigation of factors influencing biogas production in a large-scale thermophilic municipal ...
In: Applied Microbiology and Biotechnology Bd. 84 (2009) Heft 5. - S. 987-1001
doi:10.1007/s00253-009-2093-6 ...

Schubert, Sven; Freitag, Ruth
Investigation of the interaction mechanism of the recombinant human antibody MDJ8 and its fragm ...
In: Journal of Chromatography A Bd. 1216 (2009) Heft 18. - S. 3831-3840
doi:10.1016/j.chroma.2009.02.074 ...

Hilbrig, Frank; Jérôme, Valérie; Salzig, Mark; Freitag, Ruth
Strategy for the isolation of native dehydrogenases with potential for biosensor development fr ...
In: Journal of Chromatography A Bd. 1216 (2009) Heft 16. - S. 3518-3525
doi:10.1016/j.chroma.2008.09.020 ...

Parisot, Judicaël; Kurz, Katrin; Hilbrig, Frank; Freitag, Ruth
Use of azobenzene amino acids as photo-responsive conformational switches to regulate antibody– ...
In: Journal of Separation Science Bd. 32 (2009) Heft 10. - S. 1613-1624
doi:10.1002/jssc.200800698 ...

2008

Achmann, Sabine; Hermann, Markus; Hilbrig, Frank; Jérôme, Valérie; Hämmerle, Martin; Freitag, Ruth; Moos, Ralf
Direct detection of formaldehyde in air by a Novel NAD⁺- and glutathione-independent formaldehy ...
In: Talanta Bd. 75 (2008) Heft 3. - S. 786-791
doi:10.1016/j.talanta.2007.12.015 ...

Weiss, Agnes; Jérôme, Valérie; Freitag, Ruth; Mayer, Helmut K.
Diversity of the resident microbiota in a thermophilic municipal biogas plant
In: Applied Microbiology and Biotechnology Bd. 81 (2008) Heft 1. - S. 163-173
doi:10.1007/s00253-008-1717-6 ...

Stocker-Majd, Gisela; Hilbrig, Frank; Freitag, Ruth
Extraction of haemoglobin from human blood by affinity precipitation using a haptoglobin-based ...
In: Journal of Chromatography A Bd. 1194 (2008) Heft 1. - S. 57-65
doi:10.1016/j.chroma.2008.03.091 ...

Stocker, Gisela; Dumoulin, Dorothée; Vandevyver, Caroline; Hilbrig, Frank; Freitag, Ruth
Screening of a human antibody phage display library against a peptide antigen using stimuli-res ...
In: Biotechnology Progress Bd. 24 (2008) Heft 6. - S. 1314-1324
doi:10.1002/btpr.60 ...

Freitag, Ruth; Hilbrig, Frank
Use of the avidin (imino)biotin system as a general approach to affinity precipitation
Avidin-Biotin interactions : methods and applications
Totowa, NJ : Humana Press, 2008. - S. 35-50 . - (Methods in Molecular Biology; 418)

2007

Freitag, Ruth; Schumacher, Ivo; Hilbrig, Frank
Affinity precipitation an option for early capture in bioprocessing
In: Biotechnology Journal Bd. 2 (2007) Heft 6. - S. 685-690
doi:10.1002/biot.200600200 ...

Willert-Porada, Monika; Lorenz, Katrin; Freitag, Ruth; Jérôme, Valérie; Pfeiffer, Stefan
Biofilm Based Microbial Fuel Cell
NSTI Nanotech 2007
Boston, Mass. : Nano Science and Technology Institute, 2007. - S. 728-731
http://www.nsti.org/publications/Nanotech/2007/pdf ...

Schubert, Sven; Freitag, Ruth
Comparison of ceramic hydroxy- and fluoroapatite versus Protein A/G-based resins in the isolati ...
In: Journal of Chromatography A Bd. 1142 (2007) Heft 1. - S. 106-113
doi:10.1016/j.chroma.2006.08.075 ...

Weiss, Agnes; Jérôme, Valérie; Freitag, Ruth
Comparison of strategies for the isolation of PCR-compatible, genomic DNA from a municipal biog ...
In: Journal of Chromatography B Bd. 853 (2007) Heft 1-2. - S. 190-197
doi:10.1016/j.jchromb.2007.03.009 ...

Jérôme, Valérie; Hermann, Markus; Hilbrig, Frank; Freitag, Ruth
Development of a fed-batch process for the production of a dye-linked formaldehyde dehydrogenas ...
In: Applied Microbiology and Biotechnology Bd. 77 (2007) Heft 4. - S. 779-788
doi:10.1007/s00253-007-1218-z ...

O'Mahony, Kevin; Freitag, Ruth; Hilbrig, Frank; Schumacher, Ingo; Müller, Patrick
Integration of bacteria capture via filtration and in situ lysis for recovery of plasmid DNA un ...
In: Biotechnology Progress Bd. 23 (2007) Heft 4. - S. 895-903
doi:10.1021/bp0701113 ...

Vandevyver, Caroline; Canarelli, Stéphane; Bossen, Claudia; Fisch, Igor; Motmans, Kris; Raus, Jef; Freitag, Ruth
Investigation and molecular mimicry of the antigen involved in the interaction between the mono ...
In: Biotechnology and Bioengineering Bd. 97 (2007) Heft 4. - S. 721-734
doi:10.1002/bit.21276 ...

Achmann, Sabine; Hermann, Markus; Jérôme, Valérie; Hämmerle, Martin; Freitag, Ruth; Moos, Ralf
NAD-unabhängige Formaldehyddehydrogenase aus H. zavarzinii : Einsatz im Biosensor
2007
5. Deutsches Biosensor Symposium 2007, Bochum, Deutschland

Freitag, Ruth; Hilbrig, Frank
Theory and practical understanding of the migration behavior of proteins and peptides in CE and ...
In: Electrophoresis Bd. 28 (2007) Heft 13. - S. 2125-2144
doi:10.1002/elps.200600792 ...

2006

O'Mahony, Kevin; Freitag, Ruth; Dhote, Bernhard; Hilbrig, Frank; Müller, Patrick; Schumacher, Ivo
Capture of Bacteria from Fermentation Broth by Body Feed Filtration : A Solved Problem?
In: Biotechnology Progress Bd. 22 (2006) Heft 2. - S. 471-483
doi:10.1021/bp050302a ...

Pöhner, Claudia; Hilbrig, Frank; Jérôme, Valérie; Freitag, Ruth
Design and Characterization of Stimuli-Responsive FLAG-tag Analogues and the Illumination-Induc ...
In: Biotechnology Progress Bd. 22 (2006) Heft 4. - S. 1170-1178
doi:10.1021/bp060011h ...

Stocker, Gisela; Vandevyver, Caroline; Hilbrig, Frank; Freitag, Ruth
Purification of RT-PCR Competent Poly(A) mRNA from Crude Cell Lysate by Affinity Precipitation
In: Biotechnology Progress Bd. 22 (2006) Heft 6. - S. 1621-1629
doi:10.1021/bp060095u ...

2005

Jozwik, Magdalena; Kaczmarski, Krzystof; Freitag, Ruth
Investigation of the steric mass action formalism in the simulation of breakthrough curves on a ...
In: Journal of Chromatography A Bd. 1073 (2005) Heft 1-2. - S. 111-121
doi:10.1016/j.chroma.2005.01.059 ...

Desponds, Arnaud; Freitag, Ruth
Light-responsive bioconjugates as novel tools for specific capture of biologicals by photoaffin ...
In: Biotechnology and Bioengineering Bd. 91 (2005) Heft 5. - S. 583-591
doi:10.1002/bit.20479 ...

O'Mahony, Kevin; Freitag, Ruth; Hilbrig, Frank; Müller, Patrick; Schumacher, Ivo
Proposal for a better integration of bacterial lysis into the production of plasmid DNA at larg ...
In: Journal of Biotechnology Bd. 119 (2005) Heft 2. - S. 118-132
doi:10.1016/j.jbiotec.2005.03.020 ...

Yamahata, Christophe; Vandevyver, Caroline; Lacharme, Frederic; Izewska, Paulina; Vogel, Horst; Freitag, Ruth; Gijs, Martin A. M.
Pumping of mammalian cells with a nozzle-diffuser micropump
In: Lab on a Chip Bd. 5 (2005) Heft 10. - S. 1083-1088
doi:10.1039/B504468E ...

Suarez, Mougli; Haenni, Marisa; Canarelli, Stéphane; Fisch, Florian; Chodanowski, Pierre; Servis, Catherine; Michielin, Olivier; Freitag, Ruth; Moreillon, Philippe; Mermod, Nicolas
Structure-Function Characterization and Optimization of a Plant-Derived Antibacterial Peptide
In: Antimicrobial Agents and Chemotherapy Bd. 49 (2005) Heft 9. - S. 3847-3857
doi:10.1128/AAC.49.9.3847-3857.2005 ...

Szekely, Laszlo; Freitag, Ruth
Study of the electroosmotic flow as a means to propel the mobile phase in capillary electrochro ...
In: Electrophoresis Bd. 26 (2005) Heft 10. - S. 1928-1939
doi:10.1002/elps.200410194 ...

2004

Malinova, Vesela; Freitag, Ruth; Wandrey, Christine
Adsorption of charged macromolecules on oppositely charged porous column materials
In: Journal of Chromatography A Bd. 1036 (2004) Heft 1. - S. 25-32
doi:10.1016/j.chroma.2003.10.087 ...

Szucs, Veronika; Freitag, Ruth
Comparison of a three-peptide separation by capillary electrochromatography, voltage-assisted l ...
In: Journal of Chromatography A Bd. 1044 (2004) Heft 1-2. - S. 201-210
doi:10.1016/j.chroma.2004.05.103 ...

Freitag, Ruth
Comparison of the chromatographic behavior of monolithic capillary columns in capillary electro ...
In: Journal of Chromatography A Bd. 1033 (2004) Heft 2. - S. 267-273
doi:10.1016/j.chroma.2004.01.053 ...

Leiderer, M.; Ponader, Thomas; Schumacher, Matthias; Lauterbach, Anja; Hilgert, Karin; Hermann, Markus; Jérôme, Valérie; Hämmerle, Martin; Moos, Ralf; Freitag, Ruth
Elektrochemischer Enzym-Biosensor zur Detektion von gasförmigem Formaldehyd
2004
DECHEMA/GVC-Jahrestagung 2004, Karlsruhe

Lauterbach, Anja; Leiderer, M.; Ponader, P.; Schumacher, Matthias; Hämmerle, Martin; Moos, Ralf; Hermann, Markus; Jérôme, Valérie; Freitag, Ruth
Untersuchungen einer 'Dye-linked' Formaldehyddehydrogenase aus methylotrophen Bakterien
2004
BioPerspectives 2004, Wiesbaden, Deutschland

Jess, Andreas; Freitag, Ruth
Verfahren und Prozesse - nicht nur vor Gericht
In: Spektrum (2004) Heft 2. - S. 28-31
http://www.neu.uni-bayreuth.de/de/Uni_Bayreuth/Sta ...

2003

Hilbrig, Frank; Freitag, Ruth
Continuous annular chromatography
In: Journal of Chromatography B Bd. 790 (2003) Heft 1-2. - S. 1-15
doi:10.1016/S1570-0232(03)00085-0 ...

Costioli, Matteo D.; Fisch, Igor; Garret-Flaudy, Frédéric; Hilbrig, Frank; Freitag, Ruth
DNA purification by triple-helix affinity precipitation
In: Biotechnology and Bioengineering Bd. 81 (2003) Heft 5. - S. 535-545
doi:10.1002/bit.10497 ...

Hoegger, Daniela; Freitag, Ruth
Investigation of conditions allowing the synthesis of acrylamide-based monolithic microcolumns ...
In: Electrophoresis Bd. 24 (2003) Heft 17. - S. 2958-2972
doi:10.1002/elps.200305522 ...

Hoegger, Daniela; Freitag, Ruth
Investigation of mixed-mode monolithic stationary phases for the analysis of charged amino acid ...
In: Journal of Chromatography A Bd. 1004 (2003) Heft 1-2. - S. 195-208
doi:10.1016/S0021-9673(03)00563-6 ...

Schmidt, Beata; Wandrey, Christine; Freitag, Ruth
Investigation of particle-based and monolithic columns for cation exchange protein displacement ...
In: Journal of Chromatography A Bd. 1018 (2003) Heft 2. - S. 155-167
doi:10.1016/S0021-9673(03)01326-8 ...

Hilbrig, Frank; Freitag, Ruth
Protein purification by affinity precipitation
In: Journal of Chromatography B Bd. 790 (2003) Heft 1-2. - S. 79-90
doi:10.1016/S1570-0232(03)00081-3 ...

2002

Giovannini, Roberto; Freitag, Ruth
Continuous Separation of Multicomponent Protein Mixtures by Annular Displacement Chromatography
In: Biotechnology Progress Bd. 18 (2002) Heft 6. - S. 1324-1331
doi:10.1021/bp010154y ...

Canarelli, Stéphane; Fisch, Igor; Freitag, Ruth
Hyphenation of multi-dimensional chromatography and mass spectrometry for the at-line-analysis ...
In: Journal of Chromatography B Bd. 775 (2002) Heft 1. - S. 27-35
doi:10.1016/S1570-0232(02)00286-6 ...

2001

Garret-Flaudy, Frédéric; Freitag, Ruth
Use of the avidin (imino)biotin system as a general approach to affinity precipitation
In: Biotechnology and Bioengineering Bd. 71 (2001) Heft 3. - S. 223-234
doi:10.1002/1097-0290(2000)71:3<223::AID-BIT1012>3 ...

Fakultät für Ingenieurwissenschaften
Lehrstuhlinhaberin Bioprozesstechnik


Prof. Dr. Ruth Freitag

Fachgruppe Ingenieurwissenschaften

Universität Bayreuth
95447 Bayreuth

Telefon: +49 (0)921 / 55-7371
E-Mail: bioprozesstechnik@uni-bayreuth.de
Homepage: Lehrstuhl Bioprozesstechnik

Verantwortlich für die Redaktion: Claudia Trautmann

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